منابع مشابه
Human paraoxonase 2
Human paraoxonase 2 (PON2), which is a member of the paraoxonase family, possesses unique properties that distinguish it from PON1 and PON3. PON2 is ubiquitously expressed in many different tissue types and is highly expressed in the vital organs, such as the heart and lungs. Early research revealed that PON2 is exclusively intracellularly found, wherein it functions as an anti-oxidative protei...
متن کاملRegulation of Hepatic Paraoxonase-1 Expression
Serum paraoxonase-1 (PON1) is a member of the paraoxonases family (PON1, PON2, and PON3). PON1 is synthesized and secreted by the liver, and in circulation it is associated with HDL. PON1 has antioxidative properties, which are associated with the enzyme's capability to decrease oxidative stress in atherosclerotic lesions and to attenuate atherosclerosis development. Epidemiological evidence de...
متن کاملDecreased paraoxonase-2 expression in human carotids during the progression of atherosclerosis.
OBJECTIVE Many gene products involved in oxidation and inflammation are implicated in the pathogenesis of atherosclerosis. We investigated paraoxonase 2 (PON2), 5-lipoxygenase (5-LO), and 5-LO activating protein (FLAP) expression and malondialdehyde (MDA) levels in carotid lesions to assess their involvement in plaque formation. METHODS AND RESULTS We measured gene expression and MDA levels i...
متن کاملIncreased Cellular Cholesterol Content: Effect of Atorvastatin Decreased Macrophage Paraoxonase 2 Expression in Patients With Hypercholesterolemia
Therapy Is the Result of Their Increased Cellular Cholesterol Content: Effect of Atorvastatin Decreased Macrophage Paraoxonase 2 Expression in Patients With Hypercholesterolemia Print ISSN: 1079-5642. Online ISSN: 1524-4636 Copyright © 2003 American Heart Association, Inc. All rights reserved. Greenville Avenue, Dallas, TX 75231 is published by the American Heart Association, 7272 Arteriosclero...
متن کامل[Association between paraoxonase-1 and paraoxonase-2 polymorphisms and the risk of acute myocardial infarction].
INTRODUCTION AND OBJECTIVES Two particular polymorphisms, namely PON1-192 and PON2-311, in the genes encoding the antioxidant enzymes paraoxonase-1 (PON1) and paraoxonase-2 (PON2) have been associated with an increased risk of acute myocardial infarction (AMI). However, previous findings have been contradictory. The aim of this study was to investigate the association between the PON1-192 and P...
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ژورنال
عنوان ژورنال: Chemico-Biological Interactions
سال: 2016
ISSN: 0009-2797
DOI: 10.1016/j.cbi.2016.04.001